lowtiyel Testosterone gel (Androgel) (14 packages 50mg each)

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Transdermal Testosterone has been marketed heavily in the Hormone Replacement Therapy Market for the last decade. For over 50 years, testosterone therapy has been used for the treatment of hypogonadism. In recent years, there has been an increase in the use of testosterone therapy for men with late-onset hypogonadism, sometimes referred to as andropause. Testosterone therapy in older and hypogonadic men can significantly improve their sense of well-being, and lead to increases in muscle and bone mass, upper body strength, virility and libido (5). Oral delivery of unmodified testosterone is not really a viable option, due to it�s rapid first-pass metabolism, possible liver toxicity, and its relatively short half-life. Thus, injectable testosterone was used for a very long time as an effective hormone replacement method. Roughly a decade ago, alternatives to injectable and oral testosterone were developed. Originally, these alternative methods of application for testosterone meant shaving an area of the skins surface (*usually the scrotum... no, really) and attaching a testosterone patch with low, dry heat (again, no, really) like a hairdryer, which basically hot-glued the testosterone patch to the scrotum. I can�t see, for the life of me, the logic employed by the doctor who thought this method was preferable to weekly or twice-monthly injections. Luckily, this painful procedure progressed to the point where it�s at now, and you can simply apply a self sticking patch or rub some testosterone gel anywhere on your body, and get the same effect. Recently, the BALCO scandal featured many references to the gel method. I think, for an adequate understanding of these types of products, we�re going to have to take a look at both the drug (testosterone) as well as the method of administration (transdermal delivery), and see how they work together, and how they compare with testosterone injections.

Testosterone is a steroid hormone from the androgen group. In mammals, testosterone is primarily secreted in the testes of males and the ovaries of females, although small amounts are also secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid.

Testosterone, as the natural product drug and one of the most widely used AAS, is the most convenient choice for a reference drug to which all others will be compared.

Particular properties of testosterone that are of note include that it converts enzymatically both to DHT and to estradiol (estrogen). While with normal levels of testosterone these conversions are in fact desirable, with supraphysiological levels caused by drug adminstration they can be undesirable. DHT is at least three times more potent (effective per milligram) than testosterone at the androgen receptor (AR): therefore, in those tissues which convert testosterone to DHT, there is effectively three times as much androgen as elsewhere in the body. Thus, whatever level of androgen is experienced by the muscle tissue is multiplied threefold or more in the skin and in the prostate. This can be excessive. Proscar could be used to keep DHT levels more or less normalized despite heavy testosterone use, however.